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Jesse J Klein, DO, FACC

Cardiovascular Disease, Interventional Cardiology

Provider Rating



291 reviews

Visit Preparation: 4.6
Patient Recomm...: 4.7
Provider Explan...: 3.8
Office Wait Time: 4.1

The Heart Institute at Largo

1345 W Bay Dr, Suite 101
Largo, FL 33770

About Jesse J Klein

Meet Dr. Jesse Klien

Jesse J. Klein, MD, graduated from Des Moines University College of Osteopathic Medicine in Des Moines, Iowa. He completed an internship through the Ohio University College of Osteopathic Medicine in Toledo, Ohio. His internal medicine residency was at the University of Minnesota and he completed fellowships in both cardiovascular diseases and interventional cardiology at the University of Cincinnati. Dr. Klein was chief cardiology Fellow in 2007 and 2008, and was recognized with an Outstanding Cardiology Fellow's Award in 2008. He is a Fellow of the American College of Cardiology and is board certified in internal medicine, nuclear cardiology, interventional cardiology and cardiovascular diseases.

After 12 years of training Dr. Klein started practicing in Pinellas County as an active interventional cardiologist. While having performed thousands of procedures, he is also teaching other physicians and medical students. Currently, Dr. Klein is the director of non-invasive cardiology services at Largo Medical Center, and a clinical assistant professor at the NOVA Southeastern University of Osteopathic Medicine for Largo Medical Center.

Dr. Klein performs many specialized diagnostic and interventional cardiac and peripheral vascular procedures including:

Dr. Klein was the first cardiologist to successfully perform CMS approved carotid stenting at Largo Medical Center . Carotid artery stenting is a minimally invasive procedure used as an alternative to the surgery, Carotid Endarterectomy. Both are performed to help prevent strokes in certain subsets of patients. However, patient's receiving carotid stenting enjoy quicker recovery times, no general anesthesia, less discomfort, and no incisions.

Abdominal Aortic Aneurysms (AAA) surgery remains one of the most high risk surgeries. However, Dr. Klein performs minimally invasive Endovascular Aneurysm Repair (EVAR), where the aneurysm is sealed off from the inside of the aorta, making this an extraordinary low risk procedure with rapid recovery.

Peripheral artery disease (PAD) is the hardening of the arteries, and can be found in all areas of the body. Severe PAD in the lower extremities often leads to pain in the legs (claudication), poor healing wounds, or even amputation. Dr. Klein participates in Save a Limb, Save a Life Program and performs many advanced techniques of percutaneous endovascular revascularization; which allows important blood flow to return to vital organs and limbs. Given his procedures are minimally invasive most patients are able to return home the same day or the following.

Thousands of Americans each year succumb to complications of deep vein thrombosis (DVT) / pulmonary embolisms (PEs). Dr. Klein performs advanced minimally invasive therapies for this, which may include percutaneous endovascular thrombectomy, angioplasty, stenting and IVC Filter Placement. Currently, he treats patients with symptomatic acute, sub-acute, and chronic DVTs as well as certain high risk patients with PE's.

Often complications of atrial septal defects (ASDs) and patent foramen ovales (PFOs) appear later in life. Symptoms include new onset of arrhythmias, strokes, shortness of breath, and early fatigue. He closes these defects (holes) in the heart with a minimally invasive procedure that does not require surgery.

This is increased pressure in the lung arteries. These arteries come from your heart and go to your lungs to receive oxygen. There are many causes of PH and symptoms often include chest pain, shortness of breath, easy fatigue and swelling in the abdomen or legs. He works closely with pulmonary specialists by providing specialized hemodynamics inside the chambers of the heart and lung arteries. This information is essential for the further evaluation and management of the PH.

Heart artery disease remains prominent in the form of angina or myocardial infarctions (heart attacks). He utilizes the last techniques in angioplasty, stenting, Rotablator (atherectomy), Intravascular ultrasound (IVUS), Fractional Flow Reserve (FFR), optical coherence tomography (OCT), thrombectomy, and left ventricular assist device (LVAD) placement.

When he is not seeing patients, teaching other physicians or doing clinical research, Dr. Klein enjoys spending time with his beautiful wife and two children.


Medical School
Des Moines University - Osteopathic Medical Center

Ohio University College of Osteopathic Medicine - Toledo, Ohio

Internal Medicine, University of Minnesota

Cardiovascular Diseases, Interventional Cardiology - University of Cincinnati

Certifications & Memberships

American Board of Interal Medicine
Fellow of the American College of Cardiology



Procedures & Conditions

Renal & Peripheral procedures; Percutaneous closure of atrial septal defects; Echocardiography; Transesophageal Echocardiography (TEE); Cardiac Catheterization; Cardiac Pet Scan


Cardiovascular Disease
Interventional Cardiology

Office Locations

The Heart Institute at Largo
1345 W Bay Dr
Suite 101
Largo, FL 33770
Phone: (727) 581-3550
Fax: (727) 586-6190

Office Hours

Mon - Fri: 8:00am - 4:00pm